Choline metabolic process

Across TCGA patient cohorts, RNA activity of the Choline metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH7A1, STK10, and WAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Choline metabolic process activity versus ALDH7A1 in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH7A1 →	+0.474	+0.086	<.001	<.001	3	7
LSCC	STK10 →	-0.237	-0.075	<.001	<.001	3	6
GBM	WAS →	-0.430	-0.052	<.001	.005	3	6
BRCA	WIPF1 →	-0.329	-0.100	<.001	<.001	3	6
LSCC	BIN2 →	-0.450	-0.131	<.001	<.001	3	6
LSCC	CCDC88B →	-0.300	-0.072	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019695 vs ALDH7A1 — GBM

Explore this scatter interactively →