Choline metabolic process

Across TCGA cell cohorts, RNA activity of the Choline metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLASP2, TRNAU1AP, and MAP11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Choline metabolic process activity versus CLASP2 in LUNG_SCLC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLASP2 →	+1.315	+1.510	.005	.006	3	3
LUNG_NSCLC_LUAD	TRNAU1AP →	+0.959	+1.251	.004	.003	3	3
UPPER_AERODIGESTIVE_TRACT	MAP11 →	+1.234	+1.131	<.001	.008	2	3
BLOOD_Myeloma	VMA21 →	+1.080	+1.943	.001	.002	1	4
LARGE_INTESTINE	SDR42E1 →	-1.556	-0.531	<.001	.007	3	2
LARGE_INTESTINE	CHFR →	-1.599	-0.550	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019695 vs CLASP2 — LUNG_SCLC

Explore this scatter interactively →