Glyceraldehyde-3-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Glyceraldehyde-3-phosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TKT, IMPA2, and PCK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glyceraldehyde-3-phosphate metabolic process activity versus TKT in LSCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TKT →	+0.550	+0.075	<.001	<.001	3	7
GBM	IMPA2 →	+0.852	+0.075	<.001	<.001	3	6
GBM	PCK2 →	+0.415	+0.056	<.001	<.001	3	6
GBM	RBM47 →	+0.557	+0.053	<.001	<.001	3	6
LSCC	MRPS7 →	+0.359	+0.038	<.001	<.001	3	6
LSCC	SLC9A3R1_S280 →	+0.691	+0.047	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019682 vs TKT — LSCC

Explore this scatter interactively →