NAD metabolic process

Across TCGA patient cohorts, RNA activity of the NAD metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDO1, WARS1, and GBP5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NAD metabolic process activity versus IDO1 in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IDO1 →	+1.200	+0.146	.001	.004	3	8
OV	WARS1 →	+0.610	+0.172	.008	.003	3	7
OV	GBP5 →	+1.004	+0.170	<.001	<.001	3	7
OV	CCL5 →	+1.612	+0.230	<.001	<.001	3	7
GBM	LILRB1 →	+1.121	+0.169	<.001	<.001	3	7
HNSC	CCRL2 →	+0.632	+0.193	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019674 vs IDO1 — LUAD

Explore this scatter interactively →