NAD metabolic process

Across TCGA cell cohorts, RNA activity of the NAD metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCP, PPP2R5A, and ZSCAN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCP grouped by NAD metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VCP →	-0.986	-0.257	<.001	.002	3	6
STOMACH	PPP2R5A →	-0.297	-0.334	.003	.003	3	5
STOMACH	ZSCAN1 →	-0.296	-0.447	.009	.006	2	5
STOMACH	ZNF324B →	+0.383	+0.429	.005	.003	3	4
LUNG_NSCLC_LUAD	UBE2O →	-0.130	-0.187	.004	.005	2	5
LUNG_SCLC	AMER1 →	-0.395	-0.180	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCP by NAD metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →