NAD metabolic process

Across TCGA cell cohorts, RNA activity of the NAD metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP1, EZH1, and SPATA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP1 grouped by NAD metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SENP1 →	+0.957	+0.304	.001	.002	3	4
LUNG_NSCLC_LUSC	EZH1 →	+0.584	+0.271	.009	.005	3	4
LUNG_NSCLC_LUSC	SPATA5 →	+0.771	+0.296	<.001	.001	3	4
LUNG_NSCLC_LUSC	ZNF852 →	+0.843	+0.380	.001	.003	3	4
KIDNEY	VPS18 →	-0.696	-0.248	.007	.001	3	3
KIDNEY	ARGLU1 →	-0.872	-0.284	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP1 by NAD metabolic process activity — KIDNEY

Explore this box plot interactively →