NAD metabolic process

Across TCGA cell cohorts, RNA activity of the NAD metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAMPT, GDF15, and RIDA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NAD metabolic process activity versus NAMPT in BREAST (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAMPT →	+1.226	+0.239	.001	<.001	3	6
OVARY	GDF15 →	+2.636	+0.155	.008	.004	3	5
LARGE_INTESTINE	RIDA →	+1.216	+0.355	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PMCH →	+0.255	+0.290	.001	.007	3	4
BLOOD_Leukemia	STK17B →	+1.283	+0.185	.003	<.001	3	4
CNS	ARMC9 →	-0.944	-0.158	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019674 vs NAMPT — BREAST

Explore this scatter interactively →