Glucuronate catabolic process to xylulose 5-phosphate

Across TCGA patient cohorts, RNA activity of the Glucuronate catabolic process to xylulose 5-phosphate pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORD, TARS2, and STK17A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucuronate catabolic process to xylulose 5-phosphate activity versus SORD in UCEC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SORD →	+0.665	+0.122	<.001	<.001	3	8
LSCC	TARS2 →	+0.373	+0.077	<.001	<.001	3	6
GBM	STK17A →	-0.502	-0.044	.003	.006	3	6
UCEC	ECHS1 →	+0.476	+0.139	<.001	<.001	3	6
LSCC	FAM117B_S220 →	+0.311	+0.058	.001	.001	3	6
UCEC	MYO9B →	-0.321	-0.136	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019640 vs SORD — UCEC

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