Glucuronate catabolic process to xylulose 5-phosphate

Across TCGA patient cohorts, RNA activity of the Glucuronate catabolic process to xylulose 5-phosphate pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKMYT1, GTSE1, and SKA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucuronate catabolic process to xylulose 5-phosphate activity versus PKMYT1 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PKMYT1 →	-0.535	-0.069	<.001	.006	3	5
BRCA	GTSE1 →	-0.729	-0.095	.004	.004	3	5
COAD	SKA1 →	-0.722	-0.103	.001	.001	2	6
BRCA	CHEK2 →	-0.524	-0.096	.001	.005	3	5
OV	USP18 →	-0.744	-0.089	.008	.007	3	5
UCEC	MTFR2 →	-0.688	-0.093	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019640 vs PKMYT1 — LUAD

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