Glucuronate catabolic process to xylulose 5-phosphate

Across TCGA cell cohorts, RNA activity of the Glucuronate catabolic process to xylulose 5-phosphate pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPST1, IGFBP7, and CEP295NL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucuronate catabolic process to xylulose 5-phosphate activity versus TPST1 in LUNG_SCLC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TPST1 →	-0.686	-0.257	.005	.007	3	6
URINARY_TRACT	IGFBP7 →	-6.067	-0.202	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CEP295NL →	-0.080	-0.326	.009	.003	3	5
OESOPHAGUS	H2AZ1 →	+1.151	+0.452	<.001	<.001	3	5
BONE	SORD →	+2.729	+0.692	<.001	.009	3	5
BREAST	TBC1D30 →	+1.382	+0.255	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019640 vs TPST1 — LUNG_SCLC

Explore this scatter interactively →