Oxalate transport

Across TCGA patient cohorts, RNA activity of the Oxalate transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B_S155, UQCR10, and MRPL49, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxalate transport activity versus TBC1D2B_S155 in LUAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBC1D2B_S155 →	-0.270	-0.058	.004	.004	3	4
COAD	UQCR10 →	+0.430	+0.066	<.001	.001	3	4
COAD	MRPL49 →	+0.332	+0.068	<.001	.001	3	4
COAD	MRPS28 →	+0.482	+0.085	.003	<.001	3	4
LUAD	DST →	-0.324	-0.053	<.001	.009	3	4
BRCA	MRPS2 →	+0.221	+0.052	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019532 vs TBC1D2B_S155 — LUAD

Explore this scatter interactively →