Oxalate transport

Across TCGA patient cohorts, RNA activity of the Oxalate transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C3, SLC26A2, and COMMD4P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxalate transport activity versus H3C3 in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	H3C3 →	+1.223	+0.677	.003	.002	3	4
COAD	SLC26A2 →	+1.270	+0.745	<.001	<.001	3	4
PDAC	COMMD4P1 →	-0.287	-0.414	.001	<.001	3	3
UCEC	LINC01003 →	+0.420	+0.695	.008	<.001	3	3
LUAD	TMEM130 →	-1.372	-0.309	<.001	.001	3	3
LUAD	EFL1P1 →	+0.563	+0.231	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019532 vs H3C3 — LSCC

Explore this scatter interactively →