Oxalate transport

Across TCGA cell cohorts, RNA activity of the Oxalate transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGXT, SLC26A11, and FOSL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGXT grouped by Oxalate transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AGXT →	-0.266	-1.495	.004	.001	3	7
SKIN	SLC26A11 →	-0.292	-1.132	<.001	<.001	3	7
KIDNEY	FOSL2 →	-0.232	-0.745	.007	.002	3	5
BREAST	SLC26A9 →	-0.360	-0.954	<.001	.001	3	5
CNS	SLC26A3 →	-0.132	-0.612	.002	.001	3	4
BLOOD_Leukemia	BRD2 →	+0.235	+1.290	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGXT by Oxalate transport activity — SOFT_TISSUE

Explore this box plot interactively →