Oxalate transport

Across TCGA cell cohorts, RNA activity of the Oxalate transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXorf58, PLPPR3, and TOB2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CXorf58 grouped by Oxalate transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CXorf58 →	+0.245	+0.306	<.001	.002	3	3
SOFT_TISSUE	PLPPR3 →	-2.003	-1.112	.003	.007	3	3
SOFT_TISSUE	TOB2 →	-0.792	-1.156	.002	.005	3	3
SOFT_TISSUE	ITGA6 →	+1.975	+1.188	.008	.003	3	3
BONE	RAB8A →	-0.763	-2.003	.004	<.001	3	3
LUNG_NSCLC_LUAD	ACRBP →	+0.672	+0.569	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CXorf58 by Oxalate transport activity — LIVER

Explore this box plot interactively →