Peptidyl-proline hydroxylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCOLCE, COL12A1, and COL1A2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline hydroxylation activity versus PCOLCE in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCOLCE →	+0.674	+0.049	<.001	.007	3	9
BRCA	COL12A1 →	+0.757	+0.055	<.001	<.001	3	8
BRCA	COL1A2 →	+0.684	+0.053	<.001	<.001	3	8
BRCA	CRTAP →	+0.604	+0.056	<.001	<.001	3	8
GBM	FN1 →	+0.657	+0.060	<.001	<.001	3	8
BRCA	THBS2 →	+0.911	+0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019511 vs PCOLCE — GBM

Explore this scatter interactively →