Peptidyl-proline hydroxylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF6, LRRC42, and P4HA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline hydroxylation activity versus TAF6 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAF6 →	+0.360	+0.154	.008	<.001	3	4
LSCC	LRRC42 →	+0.383	+0.165	.004	.002	3	4
LSCC	P4HA1 →	+0.637	+0.174	<.001	.003	3	4
LSCC	PDK1 →	+0.366	+0.105	.001	.007	3	4
LSCC	FRRS1 →	+0.449	+0.140	.002	.004	3	4
LSCC	SPATA33 →	+0.346	+0.148	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019511 vs TAF6 — BRCA

Explore this scatter interactively →