Peptidyl-proline hydroxylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRPF3, DNAJC18, and RPP40, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRPF3 grouped by Peptidyl-proline hydroxylation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BRPF3 →	-2.093	-2.162	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DNAJC18 →	-0.823	-0.929	.006	.001	3	5
BLOOD_Lymphoma	RPP40 →	-1.550	-1.821	.007	<.001	3	4
BLOOD_Lymphoma	GCHFR →	+4.380	+1.753	.008	<.001	3	4
BLOOD_Lymphoma	THEM4 →	-1.483	-1.396	.002	.002	3	4
BLOOD_Lymphoma	ANKS1A →	-1.234	-1.873	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRPF3 by Peptidyl-proline hydroxylation activity — BLOOD_Lymphoma

Explore this box plot interactively →