Peptidyl-proline hydroxylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP3, SASH3, and GSTM5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP3 grouped by Peptidyl-proline hydroxylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PARP3 →	-0.123	-0.182	.003	.004	3	3
SKIN	SASH3 →	+0.326	+0.284	.008	.004	3	2
SKIN	GSTM5 →	+0.227	+0.207	.006	.004	3	2
SKIN	GCOM1 →	-0.130	-0.237	.008	.001	3	2
SKIN	HNRNPA1L2 →	+0.256	+0.187	.004	.002	3	2
SKIN	RSPO3 →	+0.215	+0.212	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP3 by Peptidyl-proline hydroxylation activity — BREAST

Explore this box plot interactively →