Peptidyl-proline hydroxylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBP, MTSS2, and TNFSF13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline hydroxylation activity versus DBP in BREAST (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DBP →	-1.831	-0.142	.004	.004	3	3
CNS	MTSS2 →	-1.354	-0.117	.004	.001	3	3
SKIN	TNFSF13 →	-1.417	-0.236	<.001	.002	3	3
SKIN	CRIP2 →	-3.842	-0.229	.001	.006	3	3
OESOPHAGUS	KYAT1 →	-1.053	-0.248	<.001	.005	3	2
OESOPHAGUS	DCAKD →	-1.784	-0.248	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019511 vs DBP — BREAST

Explore this scatter interactively →