Triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD33, FOLR2, and CD1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride catabolic process activity versus CD33 in GBM (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD33 →	+0.495	+0.157	.008	.005	3	5
GBM	FOLR2 →	+1.361	+0.248	.001	<.001	3	5
HNSC	CD1C →	+0.630	+0.166	.001	<.001	3	5
LUAD	GPR68 →	+0.630	+0.223	.001	<.001	3	5
HNSC	MFNG →	+0.712	+0.182	<.001	.002	3	4
GBM	LY86 →	+0.873	+0.231	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019433 vs CD33 — GBM

Explore this scatter interactively →