Alditol catabolic process

Across TCGA patient cohorts, RNA activity of the Alditol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM1P9, PFDN4, and MTFR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alditol catabolic process activity versus NPM1P9 in BRCA (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NPM1P9 →	-0.584	-0.143	<.001	<.001	3	4
CCRCC	PFDN4 →	-0.349	-0.181	<.001	<.001	3	4
CCRCC	MTFR2 →	-0.275	-0.123	.002	<.001	3	4
OV	ZNF404 →	-0.830	-0.141	<.001	.002	3	4
GBM	CEP170 →	-0.283	-0.048	<.001	.002	3	4
HNSC	SFXN2 →	+0.399	+0.081	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019405 vs NPM1P9 — BRCA

Explore this scatter interactively →