Alditol catabolic process

Across TCGA cell cohorts, RNA activity of the Alditol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORD, TKFC, and GPD2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alditol catabolic process activity versus SORD in BLOOD_Lymphoma (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SORD →	+1.141	+0.062	<.001	.004	3	15
SOFT_TISSUE	TKFC →	+0.976	+0.100	<.001	<.001	2	13
PANCREAS	GPD2 →	+1.227	+0.167	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	KRTCAP3 →	+2.159	+0.144	.005	.002	3	9
OVARY	IQANK1 →	+1.760	+0.124	.004	.001	3	9
URINARY_TRACT	ANO9 →	+2.047	+0.158	.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019405 vs SORD — BLOOD_Lymphoma

Explore this scatter interactively →