Glycolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycolipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B, RENBP, and THEMIS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid catabolic process activity versus TBC1D2B in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBC1D2B →	+0.427	+0.085	<.001	<.001	3	8
OV	RENBP →	+0.462	+0.043	.001	.006	3	7
GBM	THEMIS2 →	+0.546	+0.083	<.001	<.001	3	7
GBM	THEMIS2_T593 →	+0.647	+0.071	<.001	<.001	3	7
GBM	TRPV2 →	+0.457	+0.096	<.001	<.001	3	7
LSCC	JUP →	-0.488	-0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019377 vs TBC1D2B — GBM

Explore this scatter interactively →