Glycolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XPO7, LINC00634, and MANBA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid catabolic process activity versus XPO7 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XPO7 →	-0.452	-0.186	.002	.001	3	4
BRCA	LINC00634 →	-0.315	-0.119	.001	.004	3	4
LSCC	MANBA →	+0.506	+0.169	<.001	<.001	3	4
LSCC	ZNF395 →	-0.409	-0.081	.001	.008	3	4
GBM	RNASE2 →	+1.207	+0.240	<.001	<.001	3	4
LSCC	KRT8P46 →	+0.399	+0.115	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019377 vs XPO7 — BRCA

Explore this scatter interactively →