Glycolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycolipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GALC, GNS, and GPX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid catabolic process activity versus GALC in UCEC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GALC →	+0.499	+0.140	<.001	<.001	3	5
BRCA	GNS →	+0.377	+0.210	<.001	.001	3	5
GBM	GPX1 →	+0.391	+0.282	<.001	<.001	3	4
GBM	SIK3_T221 →	+0.653	+0.217	<.001	<.001	3	4
GBM	LUM →	+0.944	+0.308	<.001	<.001	3	4
BRCA	GLB1 →	+0.368	+0.211	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019377 vs GALC — UCEC

Explore this scatter interactively →