Glycolipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSA, NEU1, and GNS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolipid catabolic process activity versus CTSA in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CTSA →	+0.969	+1.226	<.001	<.001	3	7
OESOPHAGUS	NEU1 →	+0.902	+0.562	.003	.006	3	7
SKIN	GNS →	+1.194	+0.352	<.001	.001	3	6
LUNG_SCLC	SUMF1 →	+1.268	+1.054	<.001	.002	3	6
LUNG_SCLC	BTD →	+0.800	+1.113	<.001	<.001	3	6
LUNG_SCLC	GBA →	+1.148	+1.461	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019377 vs CTSA — LUNG_SCLC

Explore this scatter interactively →