Galactolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Galactolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAV1, REEP5_T178, and PAICS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactolipid biosynthetic process activity versus CAV1 in BRCA (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAV1 →	-0.632	-0.098	<.001	<.001	3	6
LSCC	REEP5_T178 →	-0.805	-0.139	<.001	.002	3	6
HNSC	PAICS →	+0.455	+0.106	.001	<.001	3	5
BRCA	PFDN2 →	+0.301	+0.106	<.001	.001	3	5
BRCA	RANBP2 →	+0.224	+0.148	<.001	<.001	3	5
BRCA	EEF1AKNMT →	+0.247	+0.122	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019375 vs CAV1 — BRCA

Explore this scatter interactively →