Galactolipid biosynthetic process

pathway activity — cross-omics
GO:0019375Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Galactolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF333, MAP7D3, and SFRP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACZNF333 →-0.451-0.311.006<.00133
UCECMAP7D3 →-0.848-1.109<.001<.00133
UCECSFRP2 →-2.106-1.055.002.00833
COADFOXO1 →-0.874-1.043.004.00533
GBMHID1 →+0.817+0.587<.001.00233
GBMELOVL2 →-0.883-0.322.008.00633
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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