Galactolipid metabolic process

Across TCGA patient cohorts, RNA activity of the Galactolipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UGT8, MTDH_S426, and COL6A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactolipid metabolic process activity versus UGT8 in GBM (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UGT8 →	+0.780	+0.080	<.001	<.001	3	6
LUAD	MTDH_S426 →	-0.298	-0.071	.001	.006	2	6
UCEC	COL6A3 →	-0.399	-0.046	.003	.008	3	5
HNSC	STX6 →	+0.245	+0.105	<.001	<.001	3	5
LSCC	TSN →	+0.177	+0.051	.006	.006	3	5
LUAD	HSPA13 →	-0.398	-0.092	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019374 vs UGT8 — GBM

Explore this scatter interactively →