Epoxygenase P450 pathway

Across TCGA patient cohorts, RNA activity of the Epoxygenase P450 pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT2_S165, AKR1C3, and HNMT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epoxygenase P450 pathway activity versus CNOT2_S165 in LSCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CNOT2_S165 →	-0.322	-0.077	<.001	<.001	3	4
COAD	AKR1C3 →	+0.404	+0.048	.007	.006	3	4
COAD	HNMT →	+0.281	+0.068	.001	.001	3	4
COAD	PRDX5 →	+0.570	+0.081	<.001	<.001	3	4
PDAC	TACC2_S962 →	+0.747	+0.132	<.001	<.001	3	4
PDAC	ZC3HC1_S24 →	-0.344	-0.077	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019373 vs CNOT2_S165 — LSCC

Explore this scatter interactively →