Lipoxygenase pathway

Across TCGA patient cohorts, RNA activity of the Lipoxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1A, CXCL16, and TNFAIP8L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoxygenase pathway activity versus CORO1A in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CORO1A →	+0.738	+0.176	<.001	<.001	3	5
LUAD	CXCL16 →	+0.562	+0.159	.001	<.001	3	5
LSCC	TNFAIP8L2 →	+0.416	+0.145	<.001	.001	3	5
LUAD	ICOS →	+0.656	+0.127	.005	.004	3	5
GBM	CD52 →	+0.835	+0.126	<.001	<.001	3	5
GBM	PTGER4 →	+0.645	+0.107	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019372 vs CORO1A — LSCC

Explore this scatter interactively →