Lipoxygenase pathway

Across TCGA cell cohorts, RNA activity of the Lipoxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM43, CISH, and CCDC112, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoxygenase pathway activity versus TMEM43 in OESOPHAGUS (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM43 →	+1.045	+1.855	.007	<.001	3	4
BLOOD_Lymphoma	CISH →	+3.607	+1.601	.003	<.001	3	4
SKIN	CCDC112 →	+0.480	+1.192	.001	.008	3	4
LARGE_INTESTINE	KANK3 →	+1.397	+1.059	<.001	.005	3	4
BLOOD_Lymphoma	PLA2G4C →	+1.366	+1.353	.001	<.001	3	3
LUNG_NSCLC_LUSC	ARHGEF2 →	+1.690	+1.985	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019372 vs TMEM43 — OESOPHAGUS

Explore this scatter interactively →