Cyclooxygenase pathway

Across TCGA patient cohorts, RNA activity of the Cyclooxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGDS, PTGS1, and LCNL1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclooxygenase pathway activity versus PTGDS in CHOL (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	PTGDS →	+3.759	+0.112	<.001	<.001	3	28
UCS	PTGS1 →	+2.119	+0.098	<.001	.002	2	25
UCS	LCNL1 →	+1.740	+0.101	<.001	<.001	3	22
THYM	TBC1D10C →	+1.664	+0.088	<.001	<.001	3	22
THYM	ARHGAP9 →	+1.119	+0.091	<.001	<.001	3	21
THYM	WAS →	+1.283	+0.092	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019371 vs PTGDS — CHOL

Explore this scatter interactively →