Cyclooxygenase pathway

Across TCGA cell cohorts, RNA activity of the Cyclooxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF703, HMGB3, and ADGRG6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF703 grouped by Cyclooxygenase pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF703 →	-2.331	-1.115	.002	.006	3	4
LUNG_SCLC	HMGB3 →	-1.290	-0.935	.005	.005	3	4
LUNG_NSCLC_LUSC	ADGRG6 →	+2.240	+0.792	.001	.008	3	4
SKIN	MICAL1 →	-1.502	-0.844	.001	.004	3	4
LARGE_INTESTINE	RCOR2 →	-1.135	-1.052	<.001	<.001	3	4
OESOPHAGUS	EIF2S3 →	+1.277	+1.290	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF703 by Cyclooxygenase pathway activity — STOMACH

Explore this box plot interactively →