Cyclooxygenase pathway

Across TCGA cell cohorts, RNA activity of the Cyclooxygenase pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD3, KRTAP19-3, and SIGLEC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUSD3 grouped by Cyclooxygenase pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SUSD3 →	+0.225	+0.333	.006	.003	2	5
BREAST	KRTAP19-3 →	+0.062	+0.190	<.001	<.001	3	4
CNS	SIGLEC6 →	-0.205	-0.304	.004	<.001	3	3
KIDNEY	ACKR4 →	+0.206	+0.414	.002	<.001	3	3
SKIN	PAH →	+0.295	+0.357	<.001	<.001	3	3
BONE	SSH3 →	+0.375	+0.375	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUSD3 by Cyclooxygenase pathway activity — LIVER

Explore this box plot interactively →