Cyclooxygenase pathway

Across TCGA cell cohorts, RNA activity of the Cyclooxygenase pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH5A1, MEX3A, and NELFCD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclooxygenase pathway activity versus ALDH5A1 in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALDH5A1 →	+1.103	+0.210	.001	.005	3	4
BLOOD_Leukemia	MEX3A →	+1.207	+0.128	.001	.004	3	4
LUNG_NSCLC_LUAD	NELFCD →	+0.695	+0.219	<.001	.005	3	4
LUNG_NSCLC_LUAD	TMEM106A →	-1.013	-0.261	<.001	<.001	3	4
SOFT_TISSUE	SLC39A2 →	-0.166	-0.232	.001	.003	3	4
KIDNEY	ETV4 →	+2.970	+0.472	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019371 vs ALDH5A1 — BREAST

Explore this scatter interactively →