Leukotriene biosynthetic process

Across TCGA patient cohorts, RNA activity of the Leukotriene biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTRN, CSE1L, and YME1L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene biosynthetic process activity versus UTRN in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UTRN →	+0.269	+0.080	<.001	<.001	3	8
LSCC	CSE1L →	-0.366	-0.072	<.001	<.001	3	7
CCRCC	YME1L1 →	-0.294	-0.083	.001	.005	3	7
GBM	CLIC2 →	+0.523	+0.124	<.001	<.001	3	7
LSCC	CLPX →	-0.256	-0.058	<.001	<.001	3	7
BRCA	ABI3BP →	+0.933	+0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019370 vs UTRN — GBM

Explore this scatter interactively →