Leukotriene biosynthetic process

Across TCGA patient cohorts, RNA activity of the Leukotriene biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PTGS2, and CYTIP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene biosynthetic process activity versus PLA2G4A in LSCC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLA2G4A →	+1.495	+0.292	<.001	<.001	3	10
LUAD	PTGS2 →	+1.934	+0.225	<.001	<.001	3	6
BRCA	CYTIP →	+0.887	+0.208	<.001	<.001	3	6
BRCA	GZMA →	+1.027	+0.180	<.001	.001	3	6
BRCA	TNFSF13B →	+0.663	+0.196	.001	.001	3	5
CCRCC	CLNK →	+0.495	+0.115	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019370 vs PLA2G4A — LSCC

Explore this scatter interactively →