Leukotriene biosynthetic process

Across TCGA cell cohorts, RNA activity of the Leukotriene biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, UQCRB, and COX7C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene biosynthetic process activity versus SLC1A3 in BREAST (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC1A3 →	-3.017	-0.997	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	UQCRB →	+0.938	+1.289	.001	.002	3	5
LARGE_INTESTINE	COX7C →	+0.822	+1.155	<.001	<.001	3	5
URINARY_TRACT	SAA1 →	-3.723	-1.393	.003	.001	3	5
LARGE_INTESTINE	NTN4 →	-1.956	-0.864	<.001	.008	3	5
BREAST	SAA2 →	-1.900	-0.924	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019370 vs SLC1A3 — BREAST

Explore this scatter interactively →