Arachidonic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Arachidonic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, YPEL1, and PTGS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid metabolic process activity versus PLA2G4A in COAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.631	+0.264	<.001	<.001	3	6
HNSC	YPEL1 →	-0.535	-0.250	.001	<.001	3	6
HNSC	PTGS2 →	+1.205	+0.240	.004	<.001	3	5
BRCA	PATZ1 →	-0.507	-0.154	<.001	<.001	3	4
GBM	MYEF2 →	-0.523	-0.182	.002	<.001	3	4
GBM	TNFSF9 →	+0.613	+0.134	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019369 vs PLA2G4A — COAD

Explore this scatter interactively →