Arachidonic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Arachidonic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF518A, CCNT2, and RIF1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid metabolic process activity versus ZNF518A in BONE (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF518A →	-1.046	-0.164	.001	<.001	3	12
SOFT_TISSUE	CCNT2 →	-1.016	-0.125	<.001	<.001	3	11
SOFT_TISSUE	RIF1 →	-1.006	-0.157	<.001	<.001	3	10
SOFT_TISSUE	YTHDC1 →	-0.858	-0.156	<.001	<.001	3	10
STOMACH	MBTD1 →	-1.201	-0.111	<.001	.001	3	9
SOFT_TISSUE	SLC25A36 →	-0.875	-0.181	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019369 vs ZNF518A — BONE

Explore this scatter interactively →