Arachidonic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Arachidonic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBPL5, SNTA1, and PAOX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid metabolic process activity versus OSBPL5 in LUNG_NSCLC_LUSC (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OSBPL5 →	+2.125	+0.478	<.001	.002	3	4
URINARY_TRACT	SNTA1 →	+1.215	+0.218	<.001	<.001	3	3
URINARY_TRACT	PAOX →	+0.936	+0.192	.002	.004	3	3
URINARY_TRACT	EID1 →	+0.783	+0.208	.008	.001	3	3
SOFT_TISSUE	GAREM2 →	-1.907	-0.179	<.001	.005	3	3
LUNG_SCLC	DSN1 →	+0.402	+0.256	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019369 vs OSBPL5 — LUNG_NSCLC_LUSC

Explore this scatter interactively →