"Fatty acid elongation, saturated fatty acid"

Across TCGA patient cohorts, RNA activity of the "Fatty acid elongation, saturated fatty acid" pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HOOK1, CLINT1, and RBM47, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fatty acid elongation, saturated fatty acid" activity versus HOOK1 in PDAC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HOOK1 →	+0.345	+0.085	<.001	<.001	3	7
COAD	CLINT1 →	+0.232	+0.072	.001	.001	3	6
CCRCC	RBM47 →	+0.326	+0.097	<.001	<.001	3	6
LUAD	BASP1 →	-0.737	-0.085	<.001	<.001	3	5
PDAC	TRIM2_S428 →	+0.609	+0.091	.007	.002	3	5
CCRCC	AFAP1 →	-0.322	-0.073	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019367 vs HOOK1 — PDAC

Explore this scatter interactively →