Pyridine nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyridine nucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP8L, ZMYM2, and CLNS1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine nucleotide biosynthetic process activity versus AKAP8L in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKAP8L →	-0.328	-0.044	.002	.002	3	6
LSCC	ZMYM2 →	-0.277	-0.037	.007	.002	3	5
LSCC	CLNS1A →	-0.334	-0.048	<.001	<.001	3	5
LSCC	STK10 →	+0.299	+0.042	.003	.005	3	5
COAD	PRAM1 →	+0.726	+0.035	.002	.002	2	6
LSCC	RGS14_S203 →	+0.535	+0.026	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019363 vs AKAP8L — OV

Explore this scatter interactively →