Pyridine nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyridine nucleotide biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGIS, ZNF397, and CLK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGIS grouped by Pyridine nucleotide biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTGIS →	-0.183	-0.988	<.001	<.001	3	5
CNS	ZNF397 →	-0.209	-1.123	.001	<.001	3	4
SOFT_TISSUE	CLK4 →	-0.248	-0.403	.003	.003	3	4
LUNG_NSCLC_LUAD	KPNA4 →	-0.258	-0.715	.002	.008	2	5
OESOPHAGUS	SLC22A13 →	-0.305	-0.326	.005	.008	2	5
STOMACH	ZNF324B →	+0.427	+0.988	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGIS by Pyridine nucleotide biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →