Phenol-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, MAOB, and NXF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound catabolic process activity versus SF3B3 in GBM (Pearson r = -0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B3 →	-0.256	-0.132	.001	<.001	3	8
GBM	MAOB →	+0.817	+0.147	<.001	<.001	3	7
GBM	NXF1 →	-0.234	-0.084	<.001	<.001	3	7
UCEC	BAG3 →	+0.323	+0.086	<.001	<.001	3	7
BRCA	HEATR1 →	-0.322	-0.093	.001	<.001	3	7
GBM	RNPS1 →	-0.332	-0.116	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019336 vs SF3B3 — GBM

Explore this scatter interactively →