Phenol-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, TICRR, and ABCA8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound catabolic process activity versus C7 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C7 →	+1.383	+0.145	.002	<.001	3	6
UCEC	TICRR →	-0.719	-0.198	.007	<.001	3	6
UCEC	ABCA8 →	+1.107	+0.136	<.001	<.001	3	6
UCEC	KIF2C →	-1.148	-0.211	.001	<.001	3	6
UCEC	CDCA5 →	-1.201	-0.208	<.001	<.001	3	6
BRCA	CD300LG →	+0.716	+0.167	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019336 vs C7 — UCEC

Explore this scatter interactively →