Phenol-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Phenol-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, SULT1A1, and RAP1GDS1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound catabolic process activity versus FAH in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAH →	+2.080	+0.222	<.001	<.001	3	14
LIVER	SULT1A1 →	+3.057	+0.137	.001	<.001	3	8
LUNG_NSCLC_LUAD	RAP1GDS1 →	-0.531	-0.124	<.001	.001	3	8
KIDNEY	CLIC4 →	-1.400	-0.197	<.001	<.001	3	8
LUNG_NSCLC_LUAD	RIF1 →	-0.445	-0.089	<.001	.001	3	8
PANCREAS	CAMSAP1 →	-0.714	-0.168	.004	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019336 vs FAH — LUNG_SCLC

Explore this scatter interactively →