Phenol-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Phenol-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH2, SDHC, and ADAM19, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound catabolic process activity versus ALDH2 in LUNG_NSCLC_LUAD (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ALDH2 →	+2.179	+0.234	<.001	<.001	3	8
OESOPHAGUS	SDHC →	+0.844	+0.218	<.001	.001	3	5
URINARY_TRACT	ADAM19 →	-2.662	-0.480	.003	<.001	3	5
URINARY_TRACT	ADI1 →	+1.447	+0.459	.005	.001	3	5
BREAST	HGD →	+2.492	+0.343	<.001	<.001	3	5
BREAST	ANXA9 →	+1.827	+0.212	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019336 vs ALDH2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →