Pentose metabolic process

Across TCGA patient cohorts, RNA activity of the Pentose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are G6PD, LRPPRC, and SPR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pentose metabolic process activity versus G6PD in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	G6PD →	+0.679	+0.055	<.001	<.001	3	6
BRCA	LRPPRC →	+0.443	+0.040	<.001	<.001	3	5
HNSC	SPR →	+0.500	+0.068	<.001	<.001	3	5
LUAD	TKT →	+0.437	+0.084	<.001	<.001	3	5
LSCC	AKR1C3 →	+1.242	+0.045	<.001	<.001	3	5
HNSC	LIMA1_S362 →	-0.486	-0.061	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019321 vs G6PD — LSCC

Explore this scatter interactively →